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Index > Protein center > RGMA(Gene name) > Human
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  • RGMA (Gene name),
  • Repulsive guidance molecule A (Protein name ),  RGMA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RGMA(RGM);
    Protein name:
    Repulsive guidance molecule A;
    Alternative:
    RGM domain family member A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with NEO1, BMP2 and BMP4.
    Function:
    Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    450
    Sequence:
    50:
    MQPPRERLVV | TGRAGWMGMG | RGAGRSALGF | WPTLAFLLCS | FPAATSPCKI | 
    100:
    LKCNSEFWSA | TSGSHAPASD | DTPEFCAALR | SYALCTRRTA | RTCRGDLAYH | 
    150:
    SAVHGIEDLM | SQHNCSKDGP | TSQPRLRTLP | PAGDSQERSD | SPEICHYEKS | 
    200:
    FHKHSATPNY | THCGLFGDPH | LRTFTDRFQT | CKVQGAWPLI | DNNYLNVQVT | 
    250:
    NTPVLPGSAA | TATSKLTIIF | KNFQECVDQK | VYQAEMDELP | AAFVDGSKNG | 
    300:
    GDKHGANSLK | ITEKVSGQHV | EIQAKYIGTT | IVVRQVGRYL | TFAVRMPEEV | 
    350:
    VNAVEDWDSQ | GLYLCLRGCP | LNQQIDFQAF | HTNAEGTGAR | RLAAASPAPT | 
    400:
    APETFPYETA | VAKCKEKLPV | EDLYYQACVF | DLLTTGDVNF | TLAAYYALED | 
    450:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Repulsive guidance molecule A
    Cat.:
    E3256m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Repulsive guidance molecule A
    Cat.:
    E3256h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Repulsive guidance molecule A
    Cat.:
    E3256c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Repulsive guidance molecule A
    Cat.:
    U3256m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Repulsive guidance molecule A
    Cat.:
    U3256h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Repulsive guidance molecule A
    Cat.:
    U3256c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Repulsive guidance molecule A
    Cat.:
    P3256Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Repulsive guidance molecule A
    Polyclonal Antibody for Human Repulsive guidance molecule A
    Cat.:
    P3256Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Repulsive guidance molecule A
    Monoclonal Antibody for Human Repulsive guidance molecule A
    Monoclonal Antibody for Human Repulsive guidance molecule A
    Protein for Human Repulsive guidance molecule A
    Protein for Human Repulsive guidance molecule A
    Protein for Human Repulsive guidance molecule A

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      The European IMAGE consortium
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT GLU-415
      tissue: Retina.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-415
      tissue: Testis.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT GLU-415
      tissue: Teratocarcinoma.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-415
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT GLU-415
      tissue: Brain.
      tissue: Uterus.
    6. 7.
      "Unc5B associates with LARG to mediate the action of repulsive guidance molecule."
      Hata K. , Kaibuchi K. , Inagaki S. , Yamashita T.
      J. Cell Biol.184:737-750(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 8.
      "Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse."
      Endo M. , Yamashita T.
      J. Neurosci.29:6649-6662(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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