Protein name:
Repulsive guidance molecule A ;
Alternative:
RGM domain family member A ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with NEO1, BMP2 and BMP4.
Function:
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Subcellular Location:
Cell membrane
Lipid-anchor
GPI-anchor
Protein Attributes:
50:
MQPPRERLVV | TGRAGWMGMG | RGAGRSALGF | WPTLAFLLCS | FPAATSPCKI |
100:
LKCNSEFWSA | TSGSHAPASD | DTPEFCAALR | SYALCTRRTA | RTCRGDLAYH |
150:
SAVHGIEDLM | SQHNCSKDGP | TSQPRLRTLP | PAGDSQERSD | SPEICHYEKS |
200:
FHKHSATPNY | THCGLFGDPH | LRTFTDRFQT | CKVQGAWPLI | DNNYLNVQVT |
250:
NTPVLPGSAA | TATSKLTIIF | KNFQECVDQK | VYQAEMDELP | AAFVDGSKNG |
300:
GDKHGANSLK | ITEKVSGQHV | EIQAKYIGTT | IVVRQVGRYL | TFAVRMPEEV |
350:
VNAVEDWDSQ | GLYLCLRGCP | LNQQIDFQAF | HTNAEGTGAR | RLAAASPAPT |
400:
APETFPYETA | VAKCKEKLPV | EDLYYQACVF | DLLTTGDVNF | TLAAYYALED |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Chicken
ELISA Kit for Human Repulsive guidance molecule A
ELISA Kit for Human Repulsive guidance molecule A
ELISA Kit for Human Repulsive guidance molecule A
CLIA Kit for Human Repulsive guidance molecule A
CLIA Kit for Human Repulsive guidance molecule A
CLIA Kit for Human Repulsive guidance molecule A
Polyclonal Antibody for Human Repulsive guidance molecule A
Polyclonal Antibody for Human Repulsive guidance molecule A
Polyclonal Antibody for Human Repulsive guidance molecule A
Monoclonal Antibody for Human Repulsive guidance molecule A
Monoclonal Antibody for Human Repulsive guidance molecule A
Monoclonal Antibody for Human Repulsive guidance molecule A
Protein for Human Repulsive guidance molecule A
Protein for Human Repulsive guidance molecule A
Protein for Human Repulsive guidance molecule A
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT GLU-415
tissue :
Teratocarcinoma .
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-415
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT GLU-415
tissue :
Brain .
tissue :
Uterus .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION